Hotels and alternatives
Since Sousse is a major tourist destination, there are many hotels. In high season (June-early September) prices go up, but fortunately there are seldom problems finding a hotel room.
While high season prices are at least 30-40% above average for Tunisia at the same season (excluding Bizerte, which is even more expensive), prices are very comfortable in the pleasant months right before and after it. Thorugh winter, prices go even further down, but then many hotels also close.
Sousse has all classes of hotels, even if there aren't too many cheapies. As far as I could evaluate in summer 2000, your value for money rises with the standard, so Sousse might be a nice place to splurge.
Restaurants and alternatives
Sousse has a wide variety of restaurants, and many of them offer good food, charm, good service and reasonable prices at the same time. I have tested some of the typical tourist restaurants, and was surprised by the overall quality. While the rule applies to all of North Africa that restaurants with only a tourist clientele should be avoided, Sousse is a nice exception.
There are also many options along the main tourist streets for budget travellers, too. Pizzas appear to be the best the most popular option here probably in response to many Western travellers who don't get a liking for Tunisian cuisine.
Sousse has some nightlife, where the best clubs and bars are found in tourist complexes and hotels. These are not terribly much cheaper than Europe.
Sousse also has a section of seedy bars, which offer its male clientele beer and hookers. These places are easy to spot, in order to avoid or enter. It's your choice. If you're uncertain, remember that any place with a cover charge allows you to enter and have a look, before you buy your ticket. Or if you ask, the doorman will tell you what kind of place it is.
There is also a nice section of clubs with live performances. These places are generally licensed, even if there are kids running between the tables.
The beach promenade is a popular place for young Tunisians of both sexes, and it is easy to make new friends here.
All options, all over. ATMs, cash withdrawals in banks, currency change in banks and at hotels. Many shops, restaurants and hotels accept major credit cards (American Express can be a bit of a hassle).
For overland travels, Sousse has the best connections in Tunisia. It is even better than Tunis. All thinkable destinations can be reached. Fortunately, there is only one station for shared taxis, and one for buses. However, the distance between these two is too long to cover on foot if you have luggage. The train station is not too far from the bus station.
Sousse is fairly close to the airport, which it shares with Monastir. The best way of getting from/out here, is actually with the local train (end station down at the harbour), as this stops right outside the entrance to the airport.
Sousse has relatively many car rental agencies, and prices are negotiable. Never take the first offer! And also remember that international agencies not always offer impeccable service and cars, so you might as well use a local agency.